Heat shock protein 70(HSP70) is induced by elevated temperature and many other
types of stresses in cell. HSP70 ensures cell survival under stressful condition that
would lead to irreversible cell damage and ultimately to cell death. HSP70 plays
essential role in the synthesis, transport, and folding of proteins and is often refferred to
as molecular chaperones. Increased levels of HSPs occur after arthritis, infection,
inflammation, autoimmune disease and CNS injury such as infarction, ischemia, seizure
and Alzheimer's disease. Also, HSP70 increases resistance to apoptosis. The recent
studies that the expression of the HSP has been processed at various field. However,
they are still relatively little studied in clinically application, This review summarizes the
fundamental knowledge of HSP.
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